INSERM U613 BIOINFORMATICS
Supplementary information of the article "Modeling the cholesterol regulatory pathway with Boolean networks"

Simple negative regulatory loop of size 3


The model
the model

When we realize a synchronous and an asynchronous analysis
of this model of a simple negative regulatory loop of size 3,
we obtain the following finite state machines:

Synchronous Asynchronous
Finite state machine of our size-3-regulatory loop model in synchronous simulation Finite state machine of our size-3-regulatory loop model in asynchronous simulation

Shown with animated gif images, the attractors found in the synchronous dynamical analysis look like this:

Cycle 0
Cycle_0

Cycle 1
Cycle_1

The cycle 1 is identified as spurious by our method, as it should be.

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